This review will address the place of innovative, non-chemotherapy, non-CAR-T targeted therapies in the treatment of Acute Lymphoblastic Leukaemia (ALL), focusing on their use in the hematopoietic stem cell transplant (HSCT) context.The focus will be on the agent with the most experience to date, namely the bispecific T-cell engater (BiTE) blinatum
Bernabeu-Mora R, Medina-Mirapeix F, Llamazares-Herrán E, et al.Int J Chron Obstruct Pulmon Energy Support Dis.2015;10:619–2626. Page 2626, Acknowledgments section, the text “The authors wish to thank the patients and personnel of the hospital unit for their cooperation during the course of this study.The study was supported
ABSTRACT Cells stabilize intracellular inorganic phosphate (Pi) to compromise between large biosynthetic needs and detrimental bioenergetic effects of Pi.Pi homeostasis in eukaryotes uses Syg1/Pho81/Xpr1 (SPX) domains, which are receptors for inositol pyrophosphates.We explored how polymerization and storage of Pi in acidocalcisome-like vacuoles su
Abstract Background Cytochrome P450 monooxygenases (P450s) catalyze oxidation of various substrates using oxygen and NAD(P)H.Plant P450s are involved in the biosynthesis of primary and secondary metabolites performing diverse biological functions.The recent availability of the soybean genome sequence allows us to identify and analyze soybean putati